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(4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease
OtherAbstract: Statistical Manual of Mental Disorders, 4" ed., published by the American Psychiatric Association (DPalabras claves:Autores:Harrison CastroFuentes:google3, 4-Fused cyclohexyl sulfones as γ-secretase inhibitors
OtherAbstract: The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretasePalabras claves:Autores:Harrison CastroFuentes:google3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
OtherAbstract: Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused onPalabras claves:Autores:Harrison CastroFuentes:google4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
OtherAbstract: The protease γ-secretase plays a pivotal role in the synthesis of pathogenic amyloid-β in Alzheimer’Palabras claves:Autores:Harrison CastroFuentes:googleA novel series of potent γ-secretase inhibitors based on a benzobicyclo [4.2. 1] nonane core
OtherAbstract: A new series of γ-secretase inhibitors was developed from an in-house screening hit based on a benzoPalabras claves:Autores:Harrison CastroFuentes:googleDevelopment and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP
OtherAbstract: Evasion of cell death is a major cause of resistance to anti-cancer therapies, making proteins thatPalabras claves:Autores:Harrison CastroFuentes:googleDevelopment of first-in-class small molecule inhibitors of FLIP which activate caspase-8, the nodal regulator of apoptosis, necroptosis and pyroptosis
OtherAbstract: Caspase-8 is the initiator caspase for the extrinsic apoptotic pathway and now recognized as the molPalabras claves:Autores:Harrison CastroFuentes:googleCyclic sulfamide γ-secretase inhibitors
OtherAbstract: A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. ChemistPalabras claves:Autores:Harrison CastroFuentes:googleCyclic sulfamides for inhibition of gamma-secretase
OtherAbstract: Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for trPalabras claves:Autores:Harrison CastroFuentes:googleCyclohexyl sulphone derivatives as gamma-secretase inhibitors
OtherAbstract: CA 2473 374 T 2003 EP O863134 9, 1998 EP 1 466 898 10, 2004 JP 56O251. 49 3, 1981 JP 56O26847 3, 198Palabras claves:Autores:Harrison CastroFuentes:google