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A mutual self-and informant-report of cognitive complaint correlates with neuropathological outcomes in mild cognitive impairment
OtherAbstract: Background This study examines whether different sources of cognitive complaint (i.e., self and infoPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleA-28 Vascular Risk and Cognitive Decline in Older Adults with and without Mild Cognitive Impairment (MCI).
OtherAbstract: Objective: Vascular risk factors are associated with increased risk for cognitive decline and clinicPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleA/T/N polygenic risk score for cognitive decline in old age
OtherAbstract: INTRODUCTION We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A)Palabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAPOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease
OtherAbstract: Literature suggests vascular endothelial growth factor A (VEGFA) is protective among those at highesPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleCerebrospinal fluid and plasma neurofilament light relate to abnormal cognition
OtherAbstract: Introduction Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. AccPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleCerebrospinal fluid β-amyloid42 and neurofilament light relate to white matter hyperintensities
OtherAbstract: White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiolPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAssessing working memory in mild cognitive impairment with serial order recall
OtherAbstract: Background: Working memory (WM) is often assessed with serial order tests such as repeating digits bPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAssociation between common variants in RBFOX1, an RNA-binding protein, and brain amyloidosis in early and preclinical Alzheimer disease
OtherAbstract: Importance Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosisPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAssociations between verbal learning slope and neuroimaging markers across the cognitive aging spectrum
OtherAbstract: A symptom of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is a flat learning profilePalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleBiobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes
OtherAbstract: Dense genotype data and thousands of phenotypes from large biobanks, coupled with increasingly accesPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:google