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A mutual self-and informant-report of cognitive complaint correlates with neuropathological outcomes in mild cognitive impairment
OtherAbstract: Background This study examines whether different sources of cognitive complaint (i.e., self and infoPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleA-28 Vascular Risk and Cognitive Decline in Older Adults with and without Mild Cognitive Impairment (MCI).
OtherAbstract: Objective: Vascular risk factors are associated with increased risk for cognitive decline and clinicPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleA/T/N polygenic risk score for cognitive decline in old age
OtherAbstract: INTRODUCTION We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A)Palabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAPOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer’s Disease
OtherAbstract: Biomarker definitions for preclinical Alzheimer’s disease (AD) have identified individuals with neurPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAPOE genotype modifies the association between central arterial stiffening and cognition in older adults
OtherAbstract: Arterial stiffening is associated with cognitive impairment and prodromal Alzheimer's disease. ThisPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAPOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease
OtherAbstract: Literature suggests vascular endothelial growth factor A (VEGFA) is protective among those at highesPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAssociation between common variants in RBFOX1, an RNA-binding protein, and brain amyloidosis in early and preclinical Alzheimer disease
OtherAbstract: Importance Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosisPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAssociations between verbal learning slope and neuroimaging markers across the cognitive aging spectrum
OtherAbstract: A symptom of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is a flat learning profilePalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleAsymptomatic Alzheimer disease: defining resilience
OtherAbstract: Objective: To define robust resilience metrics by leveraging CSF biomarkers of Alzheimer disease (ADPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:googleBiobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes
OtherAbstract: Dense genotype data and thousands of phenotypes from large biobanks, coupled with increasingly accesPalabras claves:Autores:Jefferson Michael Acosta OrtizFuentes:google