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Bacteria Hunt Bacteria through an Intriguing Cyclic Peptide
ReviewAbstract: In the last few decades, peptides have been victorious over small molecules as therapeutics due to tPalabras claves:Antibiotics, biological activity, cyclic antimicrobial peptides, Drug Discovery, PeptidesAutores:Alberício F., B. G. De la Torre, El-Faham A., Monaim S.A.H.A., Somboro A.M.Fuentes:scopus1,3,5-Triazino Peptide Derivatives: Synthesis, Characterization, and Preliminary Antileishmanial Activity
ArticleAbstract: A library of short di-, tri-, and tetra-peptides with an s-triazine moiety at the N terminus and eitPalabras claves:1,3,5-triazine derivatives, antileishmanial compounds, morpholines, Peptides, piperidinesAutores:Abd El-Rahman M.M., Alberício F., B. G. De la Torre, Bekhit A.A., El-Faham A., Khalil H.H., Khattab S.N.Fuentes:scopus2018 FDA Tides Harvest
ReviewAbstract: In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, threPalabras claves:Dotatate, drugs, Inotersen, Lutathera, Oligonucleotides, Onpattro, Patisiran, Peptides, Pharmaceutical market, TegsediAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus2022 FDA TIDES (Peptides and Oligonucleotides) Harvest
ArticleAbstract: A total of 37 new drug entities were approved in 2022; although that year registered the lowest numbPalabras claves:drugs, FDA, gadopiclenol, lutetium ( Lu) vipivotide tetraxetan 177, Oligonucleotides, Peptides, terlipressin, tirzepatide, vutrisiranAutores:Al Musaimi O., Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopusCyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor
ArticleAbstract: Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas wPalabras claves:BDNF, Growth factors, Peptides, Secondary peptide structure mimetics, β-TurnAutores:Almeida R.D., Andreu D., B. G. De la Torre, Baeza J.L., Garcı́a-López M.T., Gerona-Navarro G., Gonzalez-Muniz R., Jaffrey S.R., Jiménez M.A., Martín-Martínez M., Santiveri C.M.Fuentes:scopusEDC·HCl and Potassium Salts of Oxyma and Oxyma-B as Superior Coupling Cocktails for Peptide Synthesis
ArticleAbstract: Nowadays, DIC is the most widely used carbodiimide for solid-phase peptide synthesis, while EDC·HClPalabras claves:peptide coupling, Peptides, solid-phase synthesis, Steric hindrance, synthetic methodsAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Khattab S.N., Kruger H.G.Fuentes:scopusNew manufacturing process to produce highly uniform resins with excellent performances in Solid Phase Peptide Synthesis
ArticleAbstract: Peptides are an important class of Active Pharmaceutical Ingbkp_redients. Thanks to the implementatiPalabras claves:Jetting manufacturing, loading, Peptides, Polystyrene, SPPS, swellingAutores:Alberício F., B. G. De la Torre, Basso A., Cheng J.I., East N.R., Jad Y.E., Kumar A., Musaimi O.A.L., Serban S., Zhichao M.A.Fuentes:scopusOxymaPure Coupling Reagents: Beyond Solid-Phase Peptide Synthesis
ArticleAbstract: OxymaPure [ethyl 2-cyano-2-(hydroxyimino)acetate] is an exceptional reagent with which to suppress rPalabras claves:amide bonds, coupling reagent, Peptides, Racemization, solid-phase synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Manne S.R.Fuentes:scopusPropylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid-Phase Peptide Synthesis
ArticleAbstract: Amidation is the predominant reaction within the pharmaceutical setting, and it is attracting greatePalabras claves:Amidation, Green Chemistry, Peptides, SPPS, T3P ®Autores:Al Musaimi O., Alberício F., B. G. De la Torre, Talbiersky P., Wisdom R.Fuentes:scopusSynthesis of New Peptide-Based Ligands with 1,2-HOPO Pendant Chelators and Thermodynamic Evaluation of Their Iron(III) Complexes**
ArticleAbstract: Hydroxypyridones (HOPOs) are an important class of chelating compounds. They bind strongly to hard mPalabras claves:Chelation, constants, Peptides, Protonation constants, Siderophore, stabilityAutores:Al Shaer D.M., Alberício F., B. G. De la TorreFuentes:scopus