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Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates
ArticleAbstract: (Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticlePalabras claves:Antitumor agents, conjugation, Dual drug delivery, Nanoparticles, Targeted therapyAutores:Bagalkot V., Basto P.A., Farokhzad O.C., Frank Alexis, Gu F.X., Jon S., Langer R.S., Radovic-Moreno A.F., Zhang L.Fuentes:scopusBiodistribution and Pharmacokinetics of Nanoprobes
Book PartAbstract:Palabras claves:Nanoparticle-based technology - factors affecting nanoprobe biodistribution and pharmacokinetics, as size, shape, surface functionality/coating and charge, Nanoprobe biodistribution and pharmacokinetics - nanoprobe toxicity, in biomedical and clinical applications, Theragnostic nanoprobes, and nanoparticle delivery systems - therapeutic vehicle with multiple examples approved by FDA for therapyAutores:Farokhzad O.C., Frank Alexis, Kolishetti N., Pridgen E.M.Fuentes:scopusAdjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release
ArticleAbstract: Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-aPalabras claves:adjuvant, CpG, R848, Resiquimod, Synthetic nanoparticle vaccine, TLR agonistAutores:Altreuter D.H., Basto P.A., Browning E.A., Farokhzad O.C., Frank Alexis, Iannacone M., Ilyinskii P.O., Johnston L.P.M., Kishimoto T.K., Langer R.S., O'Neil C.P., Pittet L.A., Radovic-Moreno A.F., Roy C.J., Shi J., Tonti E., von Andrian U.H.Fuentes:scopusEngineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
ArticleAbstract: Figure Persented: One of the major challenges in the development of targeted nanoparticles (NPs) forPalabras claves:aptamer, in vitro selection, Internalization, Nanoparticles, targeted cancer therapyAutores:Chan J.M., Cheng J., Digga E., Farokhzad O.C., Frank Alexis, Langer R.S., Levy-Nissenbaum E., Lupták A., Shi J., Teply B.A., Xiao Z.Fuentes:scopusNanoparticle technologies for cancer therapy
ReviewAbstract: Nanoparticles as drug delivery systems enable unique approaches for cancer treatment. Over the lastPalabras claves:cancer therapy, drug delivery, Metastatic cancer, Nanoparticle, TargetedAutores:Farokhzad O.C., Frank Alexis, Langer R.S., Pridgen E.M.Fuentes:scopusHER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy
ArticleAbstract: (Figure Presented) Affibodies are a class of polypeptide ligand that are potential candidates for tiPalabras claves:Affibodies, Antitumor agents, Nanoparticles, PLA-PEG copolymers, Targeted therapyAutores:Basto P.A., Farokhzad O.C., Frank Alexis, Levy-Nissenbaum E., Marein S.L., Molnar L.K., Pridgen E.M., Radovic-Moreno A.F., Wang A.Z., Westerhof K., Zhang L.Fuentes:scopusTransepithelial transport of Fc-targeted nanoparticles by the neonatal Fc receptor for oral delivery
ArticleAbstract: Nanoparticles are poised to have a tremendous impact on the treatment of many diseases, but their brPalabras claves:Autores:Blumberg R., Farokhzad O.C., Frank Alexis, Karnik R., Kuo T., Langer R.S., Levy-Nissenbaum E., Pridgen E.M.Fuentes:scopusSelf-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform
ArticleAbstract: We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug deliverPalabras claves:drug delivery, Liposome, Nanoprecipitation, Polymeric nanoparticle, self-assemblyAutores:Chan J.M., Farokhzad O.C., Frank Alexis, Gu F.X., Langer R.S., Radovic-Moreno A.F., Rhee J.W., Wang A.Z., Zhang L.Fuentes:scopusPolymeric nanoparticle drug delivery technologies for oral delivery applications
ReviewAbstract: Introduction: Many therapeutics are limited to parenteral administration. Oral administration is a dPalabras claves:chemotherapy, Inflammatory bowel disease, Insulin, M cells, mucoadhesives, mucosal vaccinations, oral delivery, Polymeric nanoparticles, transcytosisAutores:Farokhzad O.C., Frank Alexis, Pridgen E.M.Fuentes:scopusSuperparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy
ArticleAbstract: (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein wePalabras claves:doxorubicin, Nanoparticles, Superparamagnetic, TCL-SPIONAutores:Bagalkot V., Bander N.H., Cima M.J., Farokhzad O.C., Frank Alexis, Gu F.X., Jon S., Kantoff P.W., Langer R.S., Shaikh M., Vasilliou C.C., Wang A.Z., Yuet K., Zhang L.Fuentes:scopus