Mostrando 10 resultados de: 13
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Annals of the New York Academy of Sciences(1)
Apoptosis(1)
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British Journal of Pharmacology(1)
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scopus(13)
Flavopiridol: An antitumor drug with potential application in the treatment of neurodegenerative diseases
ArticleAbstract: Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerativePalabras claves:Autores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Verdaguer E.Fuentes:scopusEvidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis
ArticleAbstract: The mitochondrial peripheral benzodiazepine receptor (PBR) is involved in a functional structure desPalabras claves:AIF, Cerebellar granule cells, colchicine, Cyt c, Mitochondrial permeability transition, Peripheral benzodiazepine receptorAutores:Antoni Camins, Canudas A.M., Folch J., Jiménez A., Jordá E.G., Pallás M., Sureda F.X., Verdaguer E.Fuentes:scopusGSK-3β inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286
ArticleAbstract: The antioxidant effects of lithium and SB-415286, two glycogen synthase kinase-3β (GSK-3β) inhibitorPalabras claves:AIF, apoptosis, GSK-3β, Lithium, Oxidative Stress, SB-415286Autores:Antoni Camins, Folch J., Jiménez A., Pallás M., Rimbau V., Yeste-Velasco M.Fuentes:scopusCyclosporin A enhances colchicine-induced apoptosis in rat cerebellar granule neurons
ArticleAbstract: 1 Cyclosporin A (CsA, 1-50 μM), an immunosuppressive drug with known neurotoxic effects, did not decPalabras claves:CDK5, colchicine, Cyclosporin A, flavopiridol, Neurotoxicity, RoscovitineAutores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Rimbau V., Sureda F.X., Verdaguer E.Fuentes:scopus(±)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration
ArticleAbstract: Acetylcholinesterase inhibitors (AChEI) are among the drugs most widely used in the treatment of AlzPalabras claves:acetylcholinesterase inhibitors, Cerebellar granule cells, colchicine, neuronal death, RATAutores:Antoni Camins, Camps P., Canudas A.M., Jiménez A., Jordá E.G., Muñoz-Torrero D., Pallás M., Rimbau V., Verdaguer E.Fuentes:scopus3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons
ArticleAbstract: The mechanisms underlying selective neuronal cell death in kainic acid-mediated neurodegeneration arPalabras claves:cell cycle, Cyclin-dependent kinases, Excitotoxicity, Neurodegenerative illnessAutores:Antoni Camins, Camarasa J., Canudas A.M., Escubedo E., Jiménez A., Jordá E.G., Pallás M., Pubill D., Rimbau V., Sureda F.X., Verdaguer E.Fuentes:scopusInhibition of CDKs: A Strategy for Preventing Kainic Acid-Induced Apoptosis in Neurons
Conference ObjectAbstract: Stimulation of ionotropic glutamate receptors are implicated in neurodegenerative diseases such as APalabras claves:3-ATA, Cdk, Cerebellar granule cells, flavopiridol, Kainic acidAutores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Stranges A., Sureda F.X., Verdaguer E.Fuentes:scopusInhibition of Cell Cycle Pathway by Flavopiridol Promotes Survival of Cerebellar Granule Cells after an Excitotoxic Treatment
ArticleAbstract: Kainic acid (KA)-induced neuronal damage and the protective effects of flavopiridol were studied inPalabras claves:Autores:Antoni Camins, Canudas A.M., Jiménez A., Jordá E.G., Pallás M., Sureda F.X., Verdaguer E.Fuentes:scopusMicrogliosis and down-regulation of adenosine transporter induced by methamphetamine in rats
ArticleAbstract: Chronic administration of methamphetamine to rats induces neurotoxicity characterized by a loss of sPalabras claves:Adenosine transporter, HSP72, Methamphetamine, Peripheral-type benzodiazepine receptorAutores:Antoni Camins, Camarasa J., Escubedo E., Guitart L., Jiménez A., Pallás M., Pubill D., Sureda F.X.Fuentes:scopusNeuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis
ArticleAbstract: Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle proPalabras claves:Caspase-3, Cerebellar granule neurons, Cyclin-dependent kinases, flavopiridol, neuroprotection, Par-4Autores:Antoni Camins, Bravo R., Bruna A., Caelles C., Camarasa J., Canudas A.M., Escubedo E., Jiménez A., Jordá E.G., Pallás M., Pubill D., Verdaguer E.Fuentes:scopus