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An improved and efficient strategy for the total synthesis of a colistin-like peptide
ArticleAbstract: Polymyxins have re-emerged as the last-line therapy for treatment against extremely multi-drug resisPalabras claves:Antimicrobial peptide, colistin, Convergent method, SynthesisAutores:Alberício F., B. G. De la Torre, Govender T., Kruger H.G., Ramesh S.Fuentes:scopusGreen solid-phase peptide synthesis 4. γ-Valerolactone and N-formylmorpholine as green solvents for solid phase peptide synthesis
ArticleAbstract: Herein, we report the use of γ-valerolactone (GVL) and N-formylmorpholine (NFM) as DMF substitutes iPalabras claves:Green solvents, GVL, NFM, polystyrene resin, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Jad Y.E., Kumar A.Fuentes:scopusFacile solid-phase synthesis of head-side chain cyclothiodepsipeptides through a cyclative cleavage from MeDbz-resin
ArticleAbstract: Head to side-chain cyclothiodepsipeptides were conveniently prepared through a cyclative cleavage usPalabras claves:cyclic peptides, On resin cyclization, Solid-phase peptide synthesis, Thiolactone, ThiopeptidesAutores:Acosta G.A., Alberício F., B. G. De la Torre, Royo M.Fuentes:scopusNO as temporary guanidino-protecting group provides efficient access to Pbf-protected argininic acid
ArticleAbstract: Pbf-protected argininic acid [H-OArg(Pbf)-OH], a building block for Fmoc-solid phase peptide synthesPalabras claves:arginine, Depsipeptides, side-reactions, Solid phase peptide synthesisAutores:Alberício F., Burger K., Cupido T., Jan SpenglerFuentes:googlescopusHomologation of α-hydroxy acids to α-unsubstituted β-hydroxy carboxamides via Arndt-Eistert reaction
ArticleAbstract: Here we studied the homologation of leucic and phenyl lactic acid via Wolff-rearrangement of their dPalabras claves:Microwave shock-heating, α,β-Unsaturated carboxylic acids, α-Hydroxy diazoketones, β-Hydroxy carboxylic acidsAutores:Alberício F., Burger K., Jan Spengler, Ruíz-Rodríguez J.Fuentes:googlescopusOxyma-T, expanding the arsenal of coupling reagents
ArticleAbstract: Herein, we report a new oxime-based additive (Oxyma-T) with a similar structure to HONM and Oxyma-BPalabras claves:Carbodiimides/additives, Oxime, Peptide coupling reagent, Solid-phase peptide synthesis, Solution-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Govender T., Jad Y.E., Kruger H.G.Fuentes:scopusIncorporation of pseudoproline monomer (Fmoc-Thr[ψ<sup>Me,Me</sup>pro]–OH) facilitates efficient solid-phase synthesis of difficult peptides
ArticleAbstract: Solid-Phase Peptide Synthesis (SPPS) is a convenient and efficient method by which to prepare peptidPalabras claves:Chain to chain interaction, Deletion peptides, hGH peptide, JR Peptide, SPPSAutores:Alberício F., B. G. De la Torre, Bruckdorfer T., Manne S.R., Rustler K.Fuentes:scopusMinimizing side reactions during amide formation using DIC and oxymapure in solid-phase peptide synthesis
ArticleAbstract: N,N’-diisopropylcarbodiimide (DIC) and OxymaPure are the reagents of choice for the formation of pepPalabras claves:Carbodiimides, HCN formation, Oxadiazole, Side-reaction, Solid-phase peptide synthesisAutores:Alberício F., B. G. De la Torre, El-Faham A., Manne S.R.Fuentes:scopusγ-Valerolactone (GVL): An eco-friendly anchoring solvent for solid-phase peptide synthesis
ArticleAbstract: Due to the hazardous nature of CH2Cl2, regulatory authorities have imposed restrictions to minimizePalabras claves:Dipeptide formation, Green Chemistry, Racemization, Wang resinAutores:Al Musaimi O., Alberício F., B. G. De la Torre, Basso A., El-Faham A.Fuentes:scopusSolid-phase N-glycopeptide synthesis using allyl side-chain protected Fmoc-amino acids
ArticleAbstract: A method for the preparation of glycopeptides using a three-dimensional orthogonal solid-phase stratPalabras claves:allyl esters, glycopeptides, Orthogonal protection, solid-phase synthesisAutores:Alberício F., B. G. De la Torre, Eritja R., Kates S.Fuentes:scopus