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Asymmetric pictet-spengler reactions: Synthesis of 1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) chimeras
ArticleAbstract: A preparatively simple diastereoselective synthesis of the amino acid chimera (1S,3S)-1,2,3,4-tetrahPalabras claves:amino acids, Cyclizations, Diastereoselectivity, heterocycles, QuinolinesAutores:Broxterman Q.B., Burger K., Duchateau A.L.L., Jan Spengler, Quaedflieg P.J.L.M., Schedel H., Sieler J.Fuentes:googlescopusAsymmetric synthesis of α-unsubstituted β-hydroxy acids
ReviewAbstract: α-Unsubstituted β-hydroxy acid (3-hydroxycarboxylic acids) are constituents of various natural produPalabras claves:3-hydroxycarboxylic acids, Arndt-Eister homologation, Asymmetric aldol reactions, Asymmetric reduction, Cyclic sulfates, Cyclic sulfites, Reductive cleavage, Reformatsky reactions, β-lactonesAutores:Alberício F., Jan SpenglerFuentes:googlescopusAn efficient synthesis of N-phosphinoylmethylamino acids and some of their derivatives
ArticleAbstract: N-Phosphinoylmethylamino acid derivatives 11-18 are obtained in high yield on N-bromomethylation ofPalabras claves:Autores:Burger K., Jan SpenglerFuentes:googlescopusA new protection/activation strategy for the synthesis of naturally occurring and non-natural α-N-alkylamino acids
ReviewAbstract: A new method for the preparation of N-methylamino acids and some of their derivatives starting fromPalabras claves:amino acids, Hexafluoroacetone, Pro-Glu-chimeras, Pro-Tau-chimeras, α-N-methylamino acids, α-N-phosphinoylmethylamino acidsAutores:Burger K., Jan Spengler, Schedel H.Fuentes:googlescopusA new strategy for solid-phase depsipeptide synthesis using recoverable building blocks
ArticleAbstract: (Chemical Equation Presented) The technique of choice for synthesis of small-scale depsipeptides isPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Ruíz-Rodríguez J.Fuentes:googlescopusA novel protecting/activating strategy for β-hydroxy acids and its use in convergent peptide synthesis
ArticleAbstract: (Chemical Equation Presented) β-Hydroxy acids were reacted with hexafluoroacetone and carbodiimidesPalabras claves:Autores:Alberício F., Burger K., Jan Spengler, Royo M., Ruíz-Rodríguez J., Winter M., Yraola F.Fuentes:googlescopusCysteine-S-trityl a key derivative to prepare N-methyl cysteines
ArticleAbstract: S-Trt Cys are used as precursors for the synthesis of protected NMe-Cys. N-Methylation of Alloc-Cys(Palabras claves:Autores:Alberício F., Bayó-Puxan N., Jan Spengler, Marcucci E., Tulla-Puche J.Fuentes:googlescopusApplication of hexafluoroacetone as protecting and activating reagent in solid phase peptide and depsipeptide synthesis
ArticleAbstract: Hexafluoroacetone-protected/activated hydroxy acids [2,2- bis(trifluoromethyl)-1,3-dioxolan-4-ones]Palabras claves:Bidentate reagents, Citramalic acid, Hexafluoroacetone, Tetrahydroisoquinoline carboxylic acidAutores:Alberício F., Burger K., Cupido T., Jan Spengler, Ruiz J.Fuentes:googlescopusAmide-to-ester substitution in coiled coils: The effect of removing hydrogen bonds on protein structure
ArticleAbstract: (Figure Presented) The latest twist: The effect of backbone H-bonding on the stability of proteins wPalabras claves:Depsipeptides, Hydrogen bonds, molecular dynamics, Protein folding, SuperhelicesAutores:Alberício F., Baldauf C., Jan Spengler, Koksch B., Pisabarro M., Scheike J.Fuentes:googlescopusDomino reactions with fluorinated five-membered heterocycles - Syntheses of trifluoromethyl substituted butenolides and γ-ketoacids
ArticleAbstract: A new approach to trifluoromethyl substituted butenolides and their thioanalogues is described startPalabras claves:2-Fluoro-3-trifluoromethylfurans, 2-Fluoro-3-trifluoromethylthiophenes, Domino reactions, Trifluoromethyl substituted butenolides, α-Trifluoromethyl-γ-keto acidsAutores:Alberício F., Burger K., Fuchs A., Greif D., Hennig L., Jan SpenglerFuentes:googlescopus