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Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus
OtherAbstract: The mechanism of action of conventional antidepressants (e.g. imipramine) has been linked to modulatPalabras claves:Autores:Harrison CastroFuentes:google3, 4-Fused cyclohexyl sulfones as γ-secretase inhibitors
OtherAbstract: The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretasePalabras claves:Autores:Harrison CastroFuentes:google3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
OtherAbstract: Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused onPalabras claves:Autores:Harrison CastroFuentes:google4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
OtherAbstract: The protease γ-secretase plays a pivotal role in the synthesis of pathogenic amyloid-β in Alzheimer’Palabras claves:Autores:Harrison CastroFuentes:googleA cycloaddition-rearrangement approach to the squalestatins
OtherAbstract: Reaction of diazodiketoester 4 with methyl glyoxylate in toluene in the presence of catalytic rhodiuPalabras claves:Autores:Harrison CastroFuentes:googleA new series of potent benzodiazepine γ-secretase inhibitors
OtherAbstract: A new series of benzodiazepine-containing γ-secretase inhibitors with potential use in the treatmentPalabras claves:Autores:Harrison CastroFuentes:googleA new synthetic route to (±)-forskolin
OtherAbstract: The trans -decalin lactone (35) has been elaborated in five steps from the bromo-acetal (10) using aPalabras claves:Autores:Harrison CastroFuentes:googleA novel series of potent γ-secretase inhibitors based on a benzobicyclo [4.2. 1] nonane core
OtherAbstract: A new series of γ-secretase inhibitors was developed from an in-house screening hit based on a benzoPalabras claves:Autores:Harrison CastroFuentes:googleDevelopment of a potent and selective cell penetrant Legumain inhibitor
OtherAbstract: This Letter describes the continued SAR exploration of small molecule Legumain inhibitors with the aPalabras claves:Autores:Harrison CastroFuentes:googleCyclic sulfamide γ-secretase inhibitors
OtherAbstract: A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. ChemistPalabras claves:Autores:Harrison CastroFuentes:google