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Harnessing snake venom phospholipases A <inf>2</inf> to novel approaches for overcoming antibiotic resistance
ReviewAbstract: The emergence of antibiotic resistance drives an essential race against time to reveal new molecularPalabras claves:antibacterial peptides, antibiotic-resistant bacteria, Peptidomimetics, Phospholipase A 2, Snake venomAutores:Antonio L.V. Palacios, Bruno Mendes, Gomes P.A.D.C., Jose Rafael de Almeida, Ricardo S.P. Patiño, Saulo L. Silva, Teixeira C.A.S.Fuentes:googleorcidscopusHexafluoroacetone as a protecting and activating reagent. N- and O-glycosylation of isoserine and isocysteine *
ArticleAbstract: Starting from HFA-protected malic and thiomalic acid a series of O- and N-glycoconjugates suitable fPalabras claves:Glycoconjugates, Glycosylamines, Hexafluoroacetone, Isocyanates, malic acid, Thiomalic acidAutores:Alberício F., Böttcher C., Burger K., Hennig L., Jan SpenglerFuentes:googlescopusHexafluoroacetone as a protecting and activating reagent. Regioselective esterification of aspartic, malic, and thiomalic acid
ArticleAbstract: Hexafluoroacetone reacts with α-functionalized α,β- dicarboxy acids like aspartic, malic, and thiomaPalabras claves:Branched depsipeptides, Branched peptides, Hexafluoroacetone, Peptidomimetics, polyesterAutores:Alberício F., Burger K., Jan Spengler, Pumpor K., Windeisen E.Fuentes:googlescopusHexafluoroacetone as a protecting and activating reagent: Synthesis of new types of fluoro-substituted α-amino, α-hydroxy and α-mercapto acids
ArticleAbstract: Starting from (S)-aspartic, (S)-malic, (S)-citramalic and (S,R)-thiomalic acid, new types of 4,4-difPalabras claves:amino acids, Fluorine, Hydroxy acids, Mercapto acids, PeptidesAutores:Berger S., Burger K., El-Kousy S.M., Hennig L., Jan Spengler, Koksch B., Lange T., Osipov S.N., Tsouker P.Fuentes:googlescopusHexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides
ArticleAbstract: N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ωPalabras claves:Dielectrophiles, Hexafluoroacetone, N-Glycopeptides, N-Glycosylamino acids, N-glycosylationAutores:Böttcher C., Burger K., Essawy S.A., Jan SpenglerFuentes:googlescopusHexafluoroacetone as protecting and activating reagent. Glycosylated malic, citramalic, and thiomalic acid derivatives, new glycosylated building blocks for drug design
ArticleAbstract: Glycosylated α-hydroxy and α-mercapto acids have been synthesized starting from malic/citramalic/thiPalabras claves:3-Hydroxysuccinimido sugars, Dielectrophiles, Glycosylamines, Maleimido sugars, N-Glycosylated depsipeptides, α-Hydroxy acids, α-Hydroxyacylamino acids, α-Mercapto acids, α-Mercaptoacylamino acidsAutores:Böttcher C., Burger K., Jan SpenglerFuentes:googlescopusHexafluoroacetone as protecting and activating reagent: New routes to amino, hydroxy, and mercapto acids and their application for peptide and glyco- and depsipeptide modification
ArticleAbstract: A critical overview is given of the synthetic potential of hexafluoroacetone (HFA) as bidentate reagPalabras claves:Autores:Alberício F., Böttcher C., Burger K., Jan SpenglerFuentes:googlescopusHexafluoroacetone as protecting and activating reagent: Reactions of hexafluoroacetone with α-keto acids
ArticleAbstract: Hexafluoroacetone and α-keto acids react to give 5,5-bis(trifluoromethyl) substituted 2(5H)-furanonePalabras claves:2,2-Bis(trifluoromethyl)-1,3-dioxolan-4-ones, 5,5-Bis(trifluoromethyl)-2(5H)-furanones, 5-Trifluoromethyl-2(5H)-furanones, Butenolides, Hexafluoroacetone, Zymonic acid, α-Keto acidsAutores:Burger K., Haas A., Heistracher E., Jan Spengler, Osipov S.N.Fuentes:googlescopusHomologation of α-hydroxy acids to α-unsubstituted β-hydroxy carboxamides via Arndt-Eistert reaction
ArticleAbstract: Here we studied the homologation of leucic and phenyl lactic acid via Wolff-rearrangement of their dPalabras claves:Microwave shock-heating, α,β-Unsaturated carboxylic acids, α-Hydroxy diazoketones, β-Hydroxy carboxylic acidsAutores:Alberício F., Burger K., Jan Spengler, Ruíz-Rodríguez J.Fuentes:googlescopusExploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A<inf>2,</inf> AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom
ArticleAbstract: Phospholipases A2 (PLA2s) constitute a class of extensively studied toxins, isolated from snake venoPalabras claves:Acidic phospholipase A 2, Agkistrodon piscivorus leucostoma, Pharmacological activity, Snake venomAutores:Collaço R.C.O., de Azevedo Calderon L., González W., Jose Rafael de Almeida, Marangoni S., Ramírez D., Resende L.M., Saulo L. Silva, Schezaro-Ramos R., Simioni L.R., Soares A.M.Fuentes:orcidscopus